GeneSeek Announces Better Tests Using Higher-Density Chip

GeneSeek Announces Better Tests Using Higher-Density Chip

Neogen company says its Genomic Profiler Bovine HDTM is the beef industry's most powerful and comprehensive DNA profile.

GeneSeek has introduced a new, higher-density DNA profiling chip with even greater customization for known traits.

GeneSeek says its GeneSeek Genomic Profiler Bovine HDTM (GGP-HD) features nearly 80,000 SNPs for highly-accurate genomic-enhanced expected progeny differences (GE-EPDs), genome-wide selection, comparative genetics studies and higher density imputation. Imputation is the practice of imputing or projecting known genetic material from larger gene maps into the smaller maps created by collecting 80,000 SNPs or 50,000 SNPs.

Neogen company says its Genomic Profiler Bovine HDTM is the beef industry's most powerful and comprehensive DNA profile.

Stewart Bauck, director of beef genomics for GeneSeek, says this new technology gives beef producers a faster and more accurate genetic evaluation of their cattle at a significant cost savings. He says the new GGP-HD uses the proven Illumina Infinium chemistry.

This new product grew out of a collaboration between the U.S. Department of Agriculture, Iowa State University and GeneSeek. GeneSeek is the laboratory testing division of Neogen and Igenity is the outreach and marketing arm of Neogen

 "The GeneSeek Genomic Profiler Bovine HDTM combines many of the features of the Illumina Bovine SNP 50 panel but is enhanced with high-density content and will be more informative than a 50K product, at a much more affordable price than the Illumina 770k HD panel," says Dorian Garrick, Iowa State University Lush Chair in animal breeding and genetics and National Beef Cattle Evaluation Consortium (NBCEC) executive director.

The content of the new technology is complementary to the old and actually combines with it, Bauck says.

Better, cheaper: GeneSeek's new 80,000-SNP test panel supports Igenity's many tests for beef cattle DNA, capturing more information and doing it at a lower price.

A key goal in development of the GGP-HD was to provide beef breed associations with the most appropriate genetic markers for GE-EPDs, plus comprehensive parentage, disease and trait relevant SNPs – all for an affordable price.

"Key elements that are important to individual breeds have been factored into the product," Bauck says. "For example, the GGP-HD features hundreds of SNPs that enable the conversion from a SNP profile to microsatellite data for parentage determination from historic samples. The GGP-HD content has been specifically chosen so that it will be applicable to both purebred and crossbred cattle, making it an attractive option for all breed associations and their members, including composite cattle such as Angus cross."

The increase in accuracy of the EPD of a young sire from incorporating the GGP-HD is the equivalent to adding at least six progeny to a yearling bull for a moderately heritable trait such as marbling, Bauck says.

"Seedstock producers no longer have to wait until a bull is three years old before seeing a return on their investment. The GGP-HD allows producers to predict the true genetic potential of their bulls earlier and with more confidence to make faster genetic progress."

Beef producers can use the GeneSeek Genomic Profiler Bovine HDTM for analyses on lethal trait markers such as:

Anhidrotic Ectodermal Dysplasia (EDA-R244X); Arachnomelia-SM; Arthrogryposis (Curly Calf, AM); B-mannosidosis; Bovine Blood Coagulation Factor XIII Deficiency (F13); Brahman-Dwarfism; Calpain 316; Calpain 4751; Calpain 530; Chediak-Higashi syndrome (CHS); Chondrodysplasia-BD1; Chondrodysplasia-BD2; Color Dilutor; Congenital muscular dystonia (CMD1); Congenital muscular dystonia (CMD2); Congenital myasthenic syndrome (CMS); Contractural Arachnodactyly (Fawn Calf); Crooked Tail Syndrome-BB; Dun Color; Erythrocyte Membrane Protein Band III; Glycogen Storage Disease-Myophosphorylase; Homozygous Black Coat Color; Hypotrichosis KRT71; Hypotrichosis PMel17 (rat tail); Icthyosis Fetalis; Idiopathic Epilepsy; Igenity Profile; Leptin – several loci; Mannosidosis; Maple Syrup Urine Disease (MSUD); MFN2-Degenerative Axonopathy; Mulefoot; Neuropathic Hydrocephalus (NH); Osteopetrosis (OS); Horned/Poll; Pompes 1057 BR; Pompes 1783 SH; Pompes 2454 SH; Protoporphyria; Pseudomytonia; Pulmonary Hypoplasia with Anasarca (PHA Dexter); Pulmonary Hypoplasia with Anasarca (PHA Shorthorn); Stearoyl-CoA Desaturase (SCD1); TH-outcast; and Tibial Hemimelia (TH).

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